Cardiac glycosides inhibit TNF- /NF- B signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor
نویسندگان
چکیده
منابع مشابه
Cardiac glycosides inhibit TNF- NF- B signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor
*Department of Anatomy, Physiology, and Genetics and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814; †Cancer and Cell Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and §Protein Expression Laboratory, National Cancer Institute SAIC, Nationa...
متن کاملRecruitment of TNF Receptor 1 to Lipid Rafts Is Essential for TNF -Mediated NF- B Activation
of TNFR1 leads to the recruitment of the death domain (DD)-containing adaptor molecule TNFR1-associated death domain protein (TRADD), which serves as a platDaniel F. Legler,1,2,* Olivier Micheau,1 Marie-Agnès Doucey,1 Jürg Tschopp,1 and Claude Bron1 form to recruit additional mediators (Hsu et al., 1995, Institute of Biochemistry 1996). TRADD, in turn, binds the DD-containing Ser/ University of...
متن کاملCompartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles.
The molecular regulation of the recruitment of initial signaling complexes at the TNF-R1 is poorly defined. We demonstrate here that within minutes internalized TNF-R1 (TNF receptosomes) recruits TRADD, FADD, and caspase-8 to establish the "death-inducing signaling complex" (DISC). In addition, we identified the TNF-R1 internalization domain (TRID) required for receptor endocytosis and provide ...
متن کاملCooperation of both TNF receptors in inducing apoptosis: involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75.
TNF-R55 is the main receptor mediating TNF-induced cytotoxicity. However, in some cells TNF-R75 also signals cell death. In PC60 cells, the presence of both receptor types is required to induce apoptosis following either specific TNF-R55 or TNF-R75 triggering, pointing to a mechanism of receptor cooperation. In this study, we extend previous observations and show that TNF-R55 and TNF-R75 cooper...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2005
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0504097102